Controlled Release Strategies for the Combination of Fresh and Lyophilized Platelet-Rich Fibrin on Bone Tissue Regeneration

Figure 4

Hematoxylin and eosin staining of rat cranial defect after 6 or 12 weeks after operation. Representative light microscopic images of cranial tissue sections of the four groups: controls, fresh PRF, lyophilized PRF, and fresh/lyophilized PRF (F:L=1:1). Black arrows indicate the edge of the defect. H&E staining, (a)-(d), (i)-(l), × 10 magnification, scale bar 1mm (blue); (e)-(h), (m)-(p), × 100 magnification, scale bar 100 μm (black). NB, new bone, CT, connective tissue.