Research Article
Targeting Immune-Related Molecules in Cancer Therapy: A Comprehensive In Vitro Analysis on Patient-Derived Tumor Models
Table 1
Clinical patients’ information and molecular characterization of primary tumors used for cell line establishment.
| | | | | | T N M - classification | | | | KRAS | | TP53 | APC | | HROC | age | gender | localization | T | N | M | G | molecular subtype | adjuvant chemotherapy | survival | Exon 2 | Exon 3 | BRAF | Exon 5 | Exon 6 | Exon 7 | Exon 8 |
| | 50 T1 M5 | 67 | ♀ | Ascendens | T4 | N0 | M0 | G2 | spMSI | 1st: Capecitabine;
2nd: 5-FU/LV | alive | wt | wt | V600E | wt | wt | N239K | wt | wt | | 257 | 84 | ♀ | Ascendens | T4 | N2 | Mx | G3 | spMSI | none | †, 84 J | wt | wt | V600E | n.a. | n.a. | n.a. | n.a. | n.a. | | 60 | 71 | ♂ | Ascendens | T2 | N0 | M0 | G2 | CIMP-H | none | alive | wt | wt | wt | wt | wt | wt | R273H | Q1477 | | 183 | 59 | ♀ | Ascendens | T3 | N2 | M0 | G3 | CIMP-H | FOLFOX | alive | wt | wt | wt | R280W | R1450 | wt | mut | wt |
|
|
HROC, Hansestadt Rostock Colon; T, transfer, M - Mouse, Met, metastasis; 5-FU, 5-fluorouracil; LV, leucovorin; FOLFOX, 5-FU/LV/Oxaliplatin; May 2017, wt, wildtype; mut, mutated; n.a., not analyzed. |
