Plasma miR-22-5p, miR-132-5p, and miR-150-3p Are Associated with Acute Myocardial Infarction

Table 4

Diagnostic value of circulating selected-miRNAs for AMI.

Time point	miRNAs	AUC	95% CI	p value	Cut off value	Sensitivity	Specificity
T0	miR-22-5p	0.901	0.827-0.976	p<0.001	1.9837	0.882	0.759
	miR-132-5p	0.886	0.805-0.967	p<0.001	1.8314	0.853	0.741
	miR-150-3p	0.904	0.843-0.964	p<0.001	2.5457	0.882	0.759
	Combined score	0.942	0.893-0.991	p<0.001	2.2850	0.912	0.870
4h	miR-22-5p	0.901	0.831-0.972	p<0.001	1.8764	0.853	0.741
	miR-132-5p	0.900	0.833-0.967	p<0.001	1.8517	0.853	0.741
	miR-150-3p	0.867	0.793-0.941	p<0.001	2.5124	0.794	0.685
	Combined score	0.938	0.886-0.990	p<0.001	2.2085	0.941	0.842
8h	miR-22-5p	0.895	0.822-0.968	p<0.001	1.8569	0.853	0.741
	miR-132-5p	0.897	0.823-0.967	p<0.001	1.6987	0.882	0.759
	miR-150-3p	0.887	0.805-0.970	p<0.001	2.4592	0.882	0.759
	Combined score	0.943	0.894-0.992	p<0.001	2.1300	0.912	0.815
12h	miR-22-5p	0.895	0.815-0.975	p<0.001	2.0128	0.882	0.741
	miR-132-5p	0.909	0.851-0.967	p<0.001	1.7088	0.912	0.759
	miR-150-3p	0.859	0.778-0.941	p<0.001	2.6464	0.794	0.704
	Combined score	0.941	0.888-0.994	p<0.001	2.0900	0.912	0.852
24h	miR-22-5p	0.893	0.814-0.972	p<0.001	1.9837	0.853	0.741
	miR-132-5p	0.878	0.798-0.958	p<0.001	1.7683	0.824	0.704
	miR-150-3p	0.853	0.768-0.939	p<0.001	2.5121	0.794	0.704
	Combined score	0.936	0.883-0.989	p<0.001	2.1700	0.912	0.796
48 h	miR-22-5p	0.874	0.789-0.959	P=0.001	1.9946	0.824	0.722
	miR-132-5p	0.895	0.814-0.976	p<0.001	1.8083	0.853	0.741
72h	miR-22-5p	0.870	0.791-0.950	P=0.001	1.8744	0.794	0.704
	miR-132-5p	0.859	0.768-0.951	p<0.001	1.8334	0.853	0.722

Combined score, the combination of miR-22-5p, miR-132-5p, and miR-150-3p scores; AUC, area under the ROC curve; 95% Cl, 95% confidence interval.