Research Article
Plasma miR-22-5p, miR-132-5p, and miR-150-3p Are Associated with Acute Myocardial Infarction
Table 4
Diagnostic value of circulating selected-miRNAs for AMI.
| Time point | miRNAs | AUC | 95% CI | p value | Cut off value | Sensitivity | Specificity |
| T0 | miR-22-5p | 0.901 | 0.827-0.976 | p<0.001 | 1.9837 | 0.882 | 0.759 | | miR-132-5p | 0.886 | 0.805-0.967 | p<0.001 | 1.8314 | 0.853 | 0.741 | | miR-150-3p | 0.904 | 0.843-0.964 | p<0.001 | 2.5457 | 0.882 | 0.759 | | Combined score | 0.942 | 0.893-0.991 | p<0.001 | 2.2850 | 0.912 | 0.870 | 4h | miR-22-5p | 0.901 | 0.831-0.972 | p<0.001 | 1.8764 | 0.853 | 0.741 | | miR-132-5p | 0.900 | 0.833-0.967 | p<0.001 | 1.8517 | 0.853 | 0.741 | | miR-150-3p | 0.867 | 0.793-0.941 | p<0.001 | 2.5124 | 0.794 | 0.685 | | Combined score | 0.938 | 0.886-0.990 | p<0.001 | 2.2085 | 0.941 | 0.842 | 8h | miR-22-5p | 0.895 | 0.822-0.968 | p<0.001 | 1.8569 | 0.853 | 0.741 | | miR-132-5p | 0.897 | 0.823-0.967 | p<0.001 | 1.6987 | 0.882 | 0.759 | | miR-150-3p | 0.887 | 0.805-0.970 | p<0.001 | 2.4592 | 0.882 | 0.759 | | Combined score | 0.943 | 0.894-0.992 | p<0.001 | 2.1300 | 0.912 | 0.815 | 12h | miR-22-5p | 0.895 | 0.815-0.975 | p<0.001 | 2.0128 | 0.882 | 0.741 | | miR-132-5p | 0.909 | 0.851-0.967 | p<0.001 | 1.7088 | 0.912 | 0.759 | | miR-150-3p | 0.859 | 0.778-0.941 | p<0.001 | 2.6464 | 0.794 | 0.704 | | Combined score | 0.941 | 0.888-0.994 | p<0.001 | 2.0900 | 0.912 | 0.852 | 24h | miR-22-5p | 0.893 | 0.814-0.972 | p<0.001 | 1.9837 | 0.853 | 0.741 | | miR-132-5p | 0.878 | 0.798-0.958 | p<0.001 | 1.7683 | 0.824 | 0.704 | | miR-150-3p | 0.853 | 0.768-0.939 | p<0.001 | 2.5121 | 0.794 | 0.704 | | Combined score | 0.936 | 0.883-0.989 | p<0.001 | 2.1700 | 0.912 | 0.796 | 48 h | miR-22-5p | 0.874 | 0.789-0.959 | P=0.001 | 1.9946 | 0.824 | 0.722 | | miR-132-5p | 0.895 | 0.814-0.976 | p<0.001 | 1.8083 | 0.853 | 0.741 | 72h | miR-22-5p | 0.870 | 0.791-0.950 | P=0.001 | 1.8744 | 0.794 | 0.704 | | miR-132-5p | 0.859 | 0.768-0.951 | p<0.001 | 1.8334 | 0.853 | 0.722 |
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Combined score, the combination of miR-22-5p, miR-132-5p, and miR-150-3p scores; AUC, area under the ROC curve; 95% Cl, 95% confidence interval.
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