Eupatilin Inhibits Renal Cancer Growth by Downregulating MicroRNA-21 through the Activation of YAP1

Figure 2

Eupatilin downregulates miR-21 in renal cancer cells. (a) miR-21 expression assessed by qRT-PCR in 20 renal cancer tumor specimens (RCC) relative to that in normal adjacent renal tissues (healthy). (b) Quantification of the results in (a). Data are expressed as the mean ± SEM (n = 3) of three independent experiments. (P < 0.01 versus healthy). (c) 786-O cells were treated with Eupatilin (5, 10, or 20 mM) for 24 h. The relative expression of miR-21 in 786-O cells was assessed by qRT-PCR. Data represent the mean ± SEM (n = 3) of three independent experiments. (P < 0.01 versus control).

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