Diagnosis of Parapneumonia Pleural Effusion with Serum and Pleural Fluid Cell-Free DNA
Table 4
Receiver operating characteristic curve analysis of pleural effusion cell free DNA in diagnosis of parapneumonic effusion and its sensitivity and specificity with suggested cut-off value.
AUC
value
95% confidence interval
Cut off value
Sensitivity
Specificity
Lower limit
Upper limit
Nucleus DNA(p) (ng/ml)
0.945
<0.00
0.879
1.000
134.9
0.96
0.81
Mitochondrial DNA(p) (ng/ml)
0.889
<0.00
0.769
1.000
17.8
0.96
0.81
Nucleus DNA(s) (ng/ml)
0.804
0.660
0.948
41.8
0.86
0.69
White blood cell count (p) (×106/L)
0.893
0.758
1.000
1.285
0.81
0.90
Neutrophil(p) (%)
0.845
0.658
1.000
58
0.80
0.90
White blood cell count (s) (×109/L)
0.757
0.591
0.924
11.5
0.77
0.75
Neutrophil(s) (%)
0.645
0.132
0.461
0.829
81
0.64
0.69
AUC: area under curve; DNA: deoxyribonucleic acid; (s): serum; (p): pleural fluid; .
