Evaluation of Pathological Association between Stroke-Related QTL and Salt-Induced Renal Injury in Stroke-Prone Spontaneously Hypertensive Rat

Figure 2

Comparison of severity of renal damages among the three strains. (a–c) Typical morphology of glomerulus with no (a), partially (b), and completely (c) sclerotic change, respectively. Photos were taken at 20X. (d, e) Typical microscopic appearance from SHR (d) and Rp18.0 (e) by Azan staining after 4 weeks of salt-loading. Photos were taken at 10X. (f-g) Prevalence of sclerotic glomeruli (f) and relative fibrotic area (g) were compared among the three strains. ignificantly different from both SHR and Rp1.0 after Bonferroni’s correction (by the χ2 test). (h) Urinary protein excretion for 24h at 0, 2, and 4 weeks of salt-loading (n=6). <0.001 and ^#p<0.01 vs control SHR by Student’s t-test, which were significant after Bonferroni’s correction. Data are presented as mean ± SD.

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