Effect of eNOS on Ischemic Postconditioning-Induced Autophagy against Ischemia/Reperfusion Injury in Mice

Figure 2

IPostC decreased the structural damage induced by I/R injury. Histological images of mice hearts following 2 h of reperfusion illustrate a grossly distorted structure, nuclear vacuolation, interstitial edema, and the appearance of a frequent contraction band. These structures were largely decreased in IPostC hearts. An autophagy inhibitor 3-MA or eNOS inhibitor L-NIO abolished the protective effect of IPostC. n=6 per group.