Synaptic Injury in the Thalamus Accompanies White Matter Injury in Hypoxia/Ischemia-Mediated Brain Injury in Neonatal Rats

<div>The changes in number of oligodendrocytes and myelination. (a, b) Olig2+ cells in immunofluorescence staining referred to oligodendrocytes (scale bar = 50 <i>μ</i>m). The quantitative analysis showed decreased number of oligodendrocytes (per mm<sup>2</sup>) in subcortical white matter of right hemispheres in HI rats at 7 d after HI injury compared with sham rats. (c) Diagram of the brain region analyzed for the expression of MBP. (a, d) Immunofluorescence staining showed MBP in corpus callosum (CC) axons in the right hemispheres (boxed area in (c)) at 14 d after HI injury (scale bar = 50 <i>μ</i>m). HI rats exhibited less myelination of CC axons in the right hemispheres than sham rats did. 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BioMed Research International

fig2

Figure 2

Figure 2: Synaptic Injury in the Thalamus Accompanies White Matter Injury in Hypoxia/Ischemia-Mediated Brain Injury in Neonatal Rats 