p38/TF/HIF-α Signaling Pathway Participates in the Progression of CIPN in Mice

Figure 5

p38 inhibitor SB 203580 decreased the expression of TF in RAW 264.7 cells L-OHP treated. (a)(b) The expression of TF in RAW 264.7 cells after administrated with vehicle or L-OHP (10 μM) or p38 inhibitor SB 203580 (10 μM) (n = 4). Significant difference was revealed following one-way or two-way ANOVA ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001 vs. control; ^#P < 0.05, ^##P < 0.01, ^###P < 0.001 vs. L-OHP group; Bonferroni post hoc tests).

(a)

(b)