Consequence of Two Protocols of Social Defeat Stress on Nicotine-Induced Psychomotor Effects in Mice

Figure 6

Locomotor activity in response to methamphetamine (1.0 mg/kg, i.p.), 2 days after the long-term nicotine challenge (12 days after stress), in (a) mice previously exposed to episodic defeat protocol; (c) mice previously exposed to continuous defeat stress protocol. Figures (b) and (d) show the time course of locomotor response to methamphetamine in mice exposed to episodic and continuous protocols, respectively. +Difference between long-term saline and methamphetamine challenges (within-group comparison). In all cases, p<0.05.

(a)

(b)

(c)

(d)