Long Noncoding RNA in Preeclampsia: Transcriptional Noise or Innovative Indicators?

Table 1

Increased lncRNAs related to cellular functions of trophoblast cells in PE.

LncRNA name	Functions related to PE	Regulating gene/signal pathway	Reference
RPAIN	Inhibits invasion and promotes cell apoptosis	C1q	[40]
uc.187	Inhibits cell proliferation, invasion and increases cell apoptosis	unknown	[41]
CCAT1	Inhibits cell proliferation	CDK4	[42]
PRNCR1	Reduces cell viability	MAPK signaling pathway	[43]
DLX6-AS1	Decreases cell proliferation, migration and invasion	miR-376c/GADD45A axis	[44]
SPRY4-IT1	Decreases cell migration and proliferation, increases cell apoptosis	unknown	[45]
STOX2-IT3	Decreases cell invasion	STOX2	[46]
HELLP	Reduces cell differentiation, proliferation and invasion	YBX1, PCBP1, PCBP2, RPS6 and RPL7	[47, 48]
uc003fir	Reduces cell proliferation and migration	HIF1-α–lncRNA uc003fir–CCL5	[49]
CEACAMP8	unknown	unknown	[32]
LOC391533	unknown	unknown	[32]
LOC284100	unknown	unknown	[32]

MAPK, Mitogen-activated protein kinase.