The Neuroprotective Role of Origanum syriacum L. and Lavandula dentata L. Essential Oils through Their Effects on AMPA Receptors

Figure 2

L. dentata and O. syriacum oils alter AMPAR desensitization in a subunit-dependent manner. ((a), (b), and (c)) Illustrative normalized whole-cell current traces of AMPAR recorded upon 500 ms application of 10 mM glutamate (G, indicated above the current trace) to whole-cell recording from HEK293 cells expressing homomeric GluA1 (top), GluA2 (middle), and heteromeric GluA1/2 (bottom) alone (black) or in combination with O. syriacum (red), L. dentata (blue). The whole-cell current recording was conducted at −60 mV, pH 7.4, and 22°C. Graphs summarize weighted time constants for desensitization ( des). Data shown are mean ± SEM; n = 10–20 patches. Significance (one-way ANOVA): p < 0.05; p < 0.01; p < 0.001; ns, not significant.

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