L-Carnitine Reduces Oxidative Stress and Promotes Cells Differentiation and Bone Matrix Proteins Expression in Human Osteoblast-Like Cells

Figure 7

Effect of the inhibition of ERKs signaling on L-Carnitine (L-C) induced gene expression. The increase in OSX and OPN mRNA expression 3h after L-C was prevented by pretreating hOBs 30 min before L-C with 10µM FR180204, an inhibitor of ERKs activity. ANOVA for nonparametric data (Kruskal–Wallis) with Dunn’s multiple comparison test: <0.05, <0.01 vs control (ctrl); <0.001 vs L-C.