BioMed Research International / 2019 / Article / Fig 1

Research Article

Effect and Mechanism of Survivin on Hypoxia-Induced Multidrug Resistance of Human Laryngeal Carcinoma Cells

Figure 1

Downregulated survivin expression in hypoxic laryngeal carcinoma cells transfected with survivin-siRNA. AMC-HN-8 and Hep-2 cells were transfected with either a vector carrying a survivin targeting sequence (survivin-siRNA) or a vector carrying a survivin scrambled. Cells were cultured in hypoxia for 24 hours. By real-time quantitative RT-PCR, survivin mRNA expression in cells was detected; vs. negative and empty groups in hypoxia (a). The expression of survivin protein in Hep-2 (b) and AMC-HN-8 (c) cell lines was measured by Western blot analysis.


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