A Human Umbilical Cord Mesenchymal Stem Cell-Conditioned Medium/Chitosan/Collagen/β-Glycerophosphate Thermosensitive Hydrogel Promotes Burn Injury Healing in Mice

Figure 5

MSC-CM/hydrogel application promotes the general recovery of wounded skin in a mouse model of third-degree burns. (a) H&E stained images of wounded skin in the four groups on day 28 of wound healing: UM (unconditioned medium) group (I, II), MSC-CM group (III, IV), UM/hydrogel group (V, VI), and MSC-CM/hydrogel group (VII, VIII). Bars in I, III, V, and VII represent 100 μm and those in II, IV, VI, and VIII represent 50 μm. Statistical analyses of the epidermal thickness (b), degree of epidermal coverage (c), dermal thickness (d), and degree of dermal differentiation (e) on day 28 of wound healing. The asterisk () indicates between the compared groups.

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