Multifunctional TRPV1 Ion Channels in Physiology and Pathology with Focus on the Brain, Vasculature, and Some Visceral Systems

Figure 2

Species-related structural differences in TRPV1. (a) Phylogenetic tree constructed by CLUSTALW Multiple Sequence Alignments for several TRPV1 proteins (with accession numbers of protein sequences), namely, human (Q8NER1), rat (O35433), mouse (Q704Y3), dog (Q697L1), guinea-pig (Q6R5A3), and rabbit (Q6RX08) isoforms of TRPV1. (b) CLUSTALX 2.1 column scores for aa sequences in 6 mammalian TRPV1s shown in panel (a). A simplified protein topology is schematically shown at the top. TM: transmembrane domains. P-loop: pore-forming region.

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