Meta-Analysis of Diagnostic Performance of Instantaneous Wave-Free Ratio versus Quantitative Flow Ratio for Detecting the Functional Significance of Coronary Stenosis

Table 2

Baseline patient characteristics.

Included studies	Age (y)	Male (%)	Diabetes (%)	Smoking (%)	Hypertension (%)
Instantaneous flow ratio (iFR)
Park et al. [16]	62.8 ± 0.6	161 (68)	66 (28)	64 (27)	133 (56)
[17]	63.4 ± 10.3	(74.9)	(28.1)	(29.4)	-
ADVISE in-practice [18]	67 ± 11	247 (79)	94 (30)	160 (51)	232 (74)
ADVISE II [19]	63.6 ± 10.8	412 (68.9)	209 (35)	135 (22.6)	471 (78.8)
Fede et al. [51]	67 ± 11	41 (76)	14 (26)	-	44 (81)
Härle et al. [52]	67 ± 11	69 (63.9)	-	-	-
Indolfi et al. [26]	64 ± 9	67 (82)	14 (17)	49 (60)	61 (74)
VERIFY 2 [27]	-	136 (69)	31 (15.7)	48 (24.4)	123 (62.4)
Kanaji et al. [22]	66.6 ± 10.3	94 (79.3)	49 (40.8)	83 (69.2)	80 (63.8)
IDEAL [20]	60.6 ± 9.6	209 (69)	67 (22)	128 (43)	157 (52)
Ding et al. [53]	63.7 ± 9.6	119 (75.3)	29 (18.4)	100 (63.3)	105 (66.5)
3V FFR-FRIENDS [21]	63.8 ± 9.7	303 (77.1)	142 (36.2)	72 (18.4)	248 (63.3)
Scarsini et al. [23]	79.8 ± 9.5	84 (50)	60 (35.7)	114 (68.3)	144 (86.3)
Shiode et al. [24]	70.4 ± 8.7	77 (74.8)	40 (39)	28 (27.1)	82 (80)
Emori et al. [15]	70 ± 10	71 (71)	48 (48)	21 (21)	73 (73)
Nobre et al. [54]	67.3 ± 11	89 (64.5)	39 (28.3)	54 (39.1)	114 (82.6)
Panoulas et al. [28]	63.5 ± 12	35 (56.5)	20 (32.3)	24 (38.7)	40 (64.5)
Pisters et al. [55]	67 ± 10	246 (69)	74 (21)	50 (14)	198 (56)
Spagnoli et al. [25]	66 ± 8	35 (88)	17 (43)	10 (25)	33 (83)
Quantitative flow ratio (QFR)
FAVOR Pilot [6]	65.8 ± 8.9	61 (83.5)	17 (27.4)	-	32 (43.8)
FAVOR II CHINA [7]	61.3 ± 10.4	227 (73.7)	86 (27.9)	87 (28.2)	185 (60.1)
Yazaki et al. [29]	72.5 ± 9.5	100 (70.4)	41 (28.9)	33 (23.2)	101 (71.1)
Emori et al. [15]	70 ± 10	71 (71)	48 (48)	21 (21)	73 (73)
Emori et al. [30]	-	116 (77.3)	70 (46.7)	40 (26.7)	125 (83.3)
Mejia-Renteria et al. [32]	64.2 ± 10.3	188 (76)	94 (38)	56 (23)	164 (66)
Spitaleri et al. [31]	62 ± 11	36 (80)	4 (9)	19 (45)	29 (64)
FAVOR II Europe-Japan [33]	67 ± 10	196 (72)	78 (29)	156 (57)	201 (74)
WIFI II [34]	61 ± 8	116 (67)	18 (10)	101 (59)	121 (70)

total amount of patients in the RESOLVE study is non-available.