|
| Author (year) | Type of study | Sample | Parameter evaluated | Treatment | Results | Statistic |
|
| Cortelli et al. (2017) [27] | RCT, double blinded | 206 for 3 months | Oral Health and Quality of Life (OHQoL), pocket depth, plaque and gingival indices, PCR for bacteria evaluation, Periotron® | Gingival treatment | OHRQoL improved over time, confirming that quality of life could be changed by the treatment of oral diseases such as gingivitis | P<0.05 |
|
| Davis et al. (2018) [28] | Observational cohort study | 930 (0, 2, 4, 6 years) | Short Form-12 version (SF-12v2), Audit of Diabetes Dependent QoL 19 (ADDQoL) | Blood glucose lowering therapy | These real-life data show that treatment intensification, including insulin initiation, does not impact adversely on patient well-being in community-based type 2 diabetes | P>0.16 |
|
| Cinar et al. (2013) [29] | Prospective | 186 | Community Periodontal Need Index (CPI) HbA1c (glycated hemoglobin percentage) | Health coaching (HC), Health Education (HE) | The present findings imply that HC has a significantly higher impact on better management of diabetes and oral health when compared to formal HE | P<0.05 |
|
| Tzanetakos et al. (2018) [30] | RCT | | quality-adjusted life-years
(QALYs) | Insulin Glargine vs. Liraglutide 1.2mg vs exanatide once weekly | ExQW was estimated to be cost effective relative to IG or Lira1.2mg
for the treatment of T2DM in adults not adequately controlled on OAD | / |
|
| Islam et al. (2014) [31] | RCT | 216 for 6 months | HbA1c, quality of life | Short message service (SMS) | Mobile phone SMS services have the potential to communicate with
diabetes patients and to build awareness about the disease, improve
self-management and avoid complications also in resource-limited setting | / |
|
| Vora et al. (2015) [32] | RCT | 170+165 for 24 weeks | Diabetes Treatment Satisfaction Questionnaire | Glargine/glulisine once daily or insulin aspart/aspart protamine | In long-standing type 2 diabetes with suboptimal glycaemia despite
oral therapies and basal insulin, the basal plus regimen was noninferior to
biphasic insulin for biomedical outcomes, with a similar overall hypoglycaemia
rate but more nocturnal events | |
|
| Castro Dos Santos et al. (2016) [33] | RCT | 20 at 30, 90, 180 days | Quality of life, public health costs | Antimicrobial photodynamic therapy (aPDT) and ultrasonic periodontal debridement (UPD) | The adjunct application
of aPDT to UPD did not present additional benefits for the treatment of chronic
periodontitis in type 2 diabetic patients | P>0.05 |
|
| Goodson et al. (2017) [34] | RCT | 8173 | Salivary glucose concentration, obesity, dental caries, gingivitis | | High salivary glucose was associated with dental caries and gingivitis in the study
population | / |
|
| de Araújo Nobre et al. (2017) [35] | Open cohort study | 22009 for 3 years | Periodontitis, dental caries, and peri-implant pathology | Exposure to systemic conditions was prevented | The present study describes an epidemiological approach to the distribution and determinants of the three principal chronical oral diseases | 12.2% less periodontitis and 4.3% less dented caries |
|
| Irani et al. (2015) [36] | RCT | 61 + 74, 3 to 6 months | OHRQoL, periodontal status, OHIP-49 | Nonsurgical periodontal therapy | T2DM does not impact on overall OHRQoL as measured by OHIP-49 | there were significantly higher OHIP-49 scores (indicating poorer OHRQoL) in patients with gingivitis and periodontitis |
|
| Peer et al. (2014) [37] | RCT | / | Osteonecrosis of the jaw | Medication | Genetic predisposition for MRONJ, coupled with CYP 450 gene alterations, has been suggested to affect the degradation of medications for DM | / |
|
| Fontanari et al. (2014) [38] | review | / | Different implant surfaces on diabetic patients | / | It can be concluded that although the benefits of surface modifications present in individuals with diabetes have biological plausibility, there is little evidence of the benefits of these modifications | No significance |
|
| Cairo et al. (2001) [39] | Review | / | Periodontal disease | / | Diabetes mellitus is an important risk factor for periodontitis | / |
|
| Al-Zahrani et al. (2011) [40] | Review | / | Halitosis status, HbA1c | / | The results of this study suggest an association between halitosis and increased levels of HbA1c | P=0.03 |
|
| Domanico et al. (2015) [41] | RCT | 68 | Reactive oxygen species (ROS) | Antioxidant supplementation | Reduction of ROS levels in
patients with NPDR thanks to antioxidant therapy | P<0.001 |
|
| Semba et al. (2014) [42] | RCT | 24 for 6 weeks | Peripheral arterial
tonometry, serum and urine carboxymethyl-lysine (CML), inflammatory mediators
(interleukin-6, C-reactive protein, vascular adhesion molecule-1, and tumor
necrosis factor-α receptors I and II), soluble receptor for advanced glycation end products (AGEs), and endogenous
secretory receptor for AGEs | High or low AGEs diet | A high- or low-AGE diet had no significant
impact on peripheral arterial tonometry or any inflammatory mediators after 6 wk
of dietary intervention | ∖ |
|
| Orban et al. (2014) [43] | | 24 months | Peripheral blood immune cell subsets (CD4, CD8-naive, memory and activated
subsets, myeloid and plasmacytoid dendritic cells, monocytes, B lymphocytes,
CD4(+)CD25(high) regulatory T cells, and invariant NK T cells) | Costimulation modulator | The findings show that the
quantification of CM CD4 T cells can provide a surrogate immune marker for
C-peptide decline after the diagnosis of type 1 diabetes | / |
|
