Research Article
Association between Alanine Aminotransferase and Growth Hormone: A Retrospective Cohort Study of Short Children and Adolescents
Table 2
Comparison of anthropometric and biochemical characteristics.
| | Variables | GH peak | P value | | <5 (n = 182) | 5-10 (n = 271) | ≥10 (n = 217) |
| | Age (years) | 10.3 ± 3.2 | 10.1 ± 3.4 | 10.3 ± 3.9 | 0.634 | | BMI (kg/m2) | 17.97 ± 3.74 | 16.56 ± 2.15 | 16.28 ± 2.34 | <0.001 | | SBP (mmHg) | 105.0 ± 12.1 | 103.6 ± 11.5 | 104.9 ± 12.0 | 0.370 | | DBP (mmHg) | 63.3 ± 8.4 | 62.24 ± 8.3 | 62.7 ± 10.0 | 0.489 | | TC (mmol/L) | 3.93 ± 0.76 | 3.82 ± 0.72 | 3.76 ± 0.69 | 0.080 | | TG (mmol/L) | 0.80 ± 0.43 | 0.70 ± 0.29 | 0.67 ± 0.25 | <0.001 | | HDL-c (mmol/L) | 1.43 ± 0.44 | 1.97 ± 9.71 | 1.35 ± 0.27 | 0.507 | | LDL-c (mmol/L) | 2.28 ± 1.99 | 2.02 ± 0.59 | 2.02 ± 0.52 | 0.041 | | FPG (mmol/L) | 4.71 ± 0.70 | 4.82 ± 0.76 | 4.73 ± 0.58 | 0.202 | | Cr (mol/L) | 38.66 ± 7.69 | 40.27 ± 20.37 | 38.73 ± 10.10 | 0.403 | | UA (mol/L) | 271.41 ± 71.64 | 247.70 ± 75.90 | 272.49 ± 89.61 | 0.003 | | IGF-1 (ng/ml) | 182.56 ± 192.87 | 177.24 ± 108.56 | 202.73 ± 148.13 | 0.192 | | ALT (U/L) | 17.85 ± 9.58 | 15.18 ± 7.83 | 15.76 ± 7.13 | 0.002 | | Increased ALT (n, %) | 26 (14.29) | 20 (7.38) | 14 (6.45) | 0.012 |
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BMI: body mass index; SBP: systolic blood pressure; DBP: diastolic blood pressure; TC: total cholesterol; TG: triglycerides; HDL-c: high-density lipoprotein cholesterol; LDL-c: low-density lipoprotein cholesterol; FPG: fasting plasma glucose; UA: uric acid; GH: growth hormone; IGF-1: insulin-like growth factor-1; ALT: alanine aminotransferase.
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