Spica Prunellae Extract Enhances Fluorouracil Sensitivity of 5-Fluorouracil-Resistant Human Colon Carcinoma HCT-8/5-FU Cells via TOP2α and miR-494

Table 2

Potency of EESP in enhancing cytotoxicity of 5-FU in HCT-8/5-FU cells (n = 3).

Anticancer drugs	IC50	RF^a	RRR%^b
0.25 mg/mL EESP + 5-FU	49.46 ± 2.14	3.88	74.56
0.50 mg/mL EESP + 5-FU	7.47 ± 1.91	20.68	95.53

^aRF and ^bRRR% represent reversal effect of modulators. The greater the RF magnitude, the more significant the effect. When RRR% ≥100%, the modulator totally reversed the effect of 5-FU; when RRR% <100%, the modulator only partially reversed the effect of 5-FU.