MAPK Pathway Inhibitors Attenuated Hydrogen Peroxide Induced Damage in Neural Cells

<p>H<sub>2</sub>O<sub>2</sub>-induced cell viability was partially restored by blocking MAPK pathway. (a) Chemical structure of MAPK pathway inhibitors, including SP600125 and SB203580, targeting MEK, JNK, and p38, respectively. (b) The EC50 increased when cells were supplied with U0126 inhibitor. (c) Relative increase in EC50 by heat map. H<sub>2</sub>O<sub>2</sub>-induced cell viability was partially restored by individual MAPK inhibitor.</p>

BioMed Research International

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Figure 3

Figure 3: MAPK Pathway Inhibitors Attenuated Hydrogen Peroxide Induced Damage in Neural Cells 