Serum Amyloid A Protein as a Potential Biomarker for Severity and Acute Outcome in Traumatic Brain Injury
SAA levels peak at 1 day after injury and increase with the injury severity. Time course of acute phase proteins in response to brain injury. (a) SAA expression increases after injury in serum at 1 day after injury and returns to sham levels at 7 days after injury. At 1 day after CCI, severe injury has higher SAA expression than mild injury or sham mice as is shown by western blot (b) or by ELISA analysis (c). Protein expression in serum was normalized with GAPDH. Mean±sem, p<0.001, n=5/group.