Eliminating Risk of Intubation in Very Preterm Infants with Noninvasive Cardiorespiratory Support in the Delivery Room and Neonatal Intensive Care Unit
Table 3
Respiratory outcomes, mortality, and morbidity.
Very preterm infants, < 33 weeks gestation (GA)
Extremely low birth weight infants, < 1000 g
Variable,
2008-2010
2011-2013
2014-2017
p
p adjusted
2008-2010
2011-2013
2014-2017
p
p adjusted for
or Median (IQR)
for GA
male sex and GA
Respiratory Outcomes
NICU intubation
39
31
18
<0.001
<0.001
92
73
51
<0.001
<0.001
Pneumothorax
5
3
2
ns
ns
17
10
0
0.01
0.018
Chronic lung disease
12
13
14
ns
ns
50
46
43
ns
ns
Oxygen at discharge
5
3
2
ns
ns
23
10
11
ns
ns
Mortality and Morbidity
Mortality
6
6
2
ns
ns
19
17
11
ns
ns
Major intraventricular hemorrhage
8
6
4
ns
ns
26
19
16
ns
ns
Nosocomial infection
8
5
4
ns
ns
26
15
16
ns
ns
Severe retinopathy of prematurity
6
3
4
ns
ns
25
12
24
ns
ns
Necrotizing enterocolitis (NEC)
5
5
2
ns
ns
19
13
8
ns
ns
NEC / Spontaneous Intestinal perforation
5
5
2
ns
ns
19
15
8
ns
ns
NICU length of stay, days
37 (21 - 63)
35 (22 - 61)
39 (24 - 61)
ns
101 (69 - 116)
86 (54 - 102)
87 (64 - 107)
ns
Post menstrual age at discharge, weeks
35.9 (34.6 - 38.0)
35.9 (34.6 - 37.6)
36.1 (35.3 - 38.1)
0.008
40.0 (35.9 - 42.1)
38.4 (35.7 - 40.9)
39.1 (37.7 - 42.1)
ns
Survival without major morbidity
74
76
80
ns
ns
15
25
41
0.02
0.021
Statistically significant difference between 2008-2010 and 2011-2013. Statistically significant difference between 2008-2010 and 2014-2017. Statistically significant difference between 2011-2013 and 2014-2017.
