Neopterin and CXCL-13 in Diagnosis and Follow-Up of Trypanosoma brucei gambiense Sleeping Sickness: Lessons from the Field in Angola

Table 2

Sensitivity and specificity of new tests for staging.

	Neopterin (nmol/L)	CXCL-13 (pg/mL)
Non-stage 1	15.57	91.21
Sensitivity [IC]	0.90 [0.73; 0.98]	0.90 [0.73; 0.98]
Specificity [IC]	0.86 [0.74; 0.94]	0.79 [0.66; 0.89]
Int stage
Sensitivity [IC]	0.65 [0.43; 0.84]	0.52 [0.31; 0.73]
Specificity [IC]	0.94 [0.85; 0.98]	0.95 [0.87; 0.99]
Ad stage 2	60.31	395.45
Sensitivity [IC]	0.97 [0.85; 1.00]	0.90 [0.85; 1.00]
Specificity [IC]	1.00 [0.93; 1.00]	0.86 [0.93; 1.00]

The cut-off values established for neopterin and CXCL-13 are expressed in nmol/L and pg/mL, respectively. The sensitivity and specificity values for each cut-off points determined by ROC analysis are shown in the table. The authors defined cut-off values of neopterin and CXCL-13 for non-stage 1 patients, under which patients are considered to be in stage 1 of sleeping sickness.