Neopterin and CXCL-13 in Diagnosis and Follow-Up of Trypanosoma brucei gambiense Sleeping Sickness: Lessons from the Field in Angola
Table 3
Comparison of neopterin and CXCL-13 results to classical markers (quantitative and qualitative data).
Cut-off
Neurological signs
Sleep disorders
Trypanosomes in CSF
CXCL-131
310.52
330.26
310.52
Sensitivity [IC]
0.63 [0.49; 0.76]
0.63 [0.48; 0.77]
0.79 [0.63; 0.90]
Specificity [IC]
0.92 [0.77; 0.99]
0.92 [0.78; 0.98]
0.90 [0.78; 0.97]
Neopterin2
21.20
21.20
31.41
Sensitivity [IC]
0.69 [0.54; 0.81]
0.69 [0.55; 0.82]
0.84 [0.69; 0.94]
Specificity [IC]
0.83 [0.67; 0.94]
0.82 [0.68; 0.92]
0.90 [0.78; 0.97]
WBC count3
12
16
50
Sensitivity [IC]
0.71 [0.56; 0.83]
0.71 [0.57; 0.83]
0.82 [0.66; 0.92]
Specificity [IC]
0.92 [0.78; 0.98]
0.89 [0.76; 0.97]
0.84 [0.70; 0.93]
The determined cut-off values of neopterin, CXCL-13, and leucocyte numbers at the appearance of clinical signs of the disease (neurological signs and sleep disorders) and CNS invasion by the parasite. 1pg/mL. 2nmol/L. 3cells/μL CSF.
