Circulating Exosomes Derived-miR-146a from Systemic Lupus Erythematosus Patients Regulates Senescence of Mesenchymal Stem Cells

Figure 4

miR-146a directly targeted TRAF6 and inhibited TRAF6-NF-κB signaling expression. (a) TargetScan was used to identify putative seed-matching sites between miR-146a and 3’-UTR of TRAF6. (b, c) NOR MSCs were transfected with miR-146a inhibitors, and SLE MSCs were transfected with miR-146a mimics. After being transfected, each cell was detected for TRAF6 and p-p65 expression levels (^∗P < 0.05 compared with the normal group, ^#P < 0.05 compared with the SLE group).

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