Lactobacillus iners Is Associated with Vaginal Dysbiosis in Healthy Pregnant Women: A Preliminary Study
Table 3
Comparison of the relative abundance of vaginal bacteria by quantitative real-time PCR according to trimesters of pregnancy.
Species
Participants in 1st trimester (n = 33)
Participants in 2nd trimester (n = 24)
Participants in 3rd trimester (n = 26)
value
Lactobacillus genus (%)
31.57 (23.94)
59.80 (21.96) b
64.14 (21.61) b
<0.001
L. jensenii (%)a
0.07 (0.32)
0.43 (2.07)
0.27 (1.31)
0.633
L. crispatus (%)a
5.74 (10.39)
13.21 (12.96) c
9.67 (10.47)
0.030
L. iners (%)a
14.86 (19.74)
4.16 (7.97) d
5.02 (7.24) d
<0.001
Atopobium vaginae (%)
1.21 (3.17)
2.63 (12.86)
0.03 (0.16)
0.897
Gardnerella vaginalis (%)
0.10 (0.24)
0.08 (0.34)
2.49 (12.67)
0.944
Eggerthella (%)
0.05 (0.21)
0.00 (0.00)
0.00 (0.00)
0.466
Leptotrichia/Sneathia (%)
0.04 (0.12)
0.00 (0.00)
0.00 (0.00)
0.432
Megasphaera type (%)
0.29 (0.80)
0.02 (0.10)
0.02 (0.09)
0.569
Prevotella (%)
0.19 (0.45)
0.00 (0.01)
0.09 (0.45)
0.169
All data are mean (standard deviation). aThe relative abundance of L. crispatus, L. jensenii, and L. iners was compared to the copy number of Lactobacillus genus; bcompared with 1st trimester, ;ccompared with 1st trimester, ;dcompared with 1st trimester, .
