Focused Ultrasound Effects on Osteosarcoma Cell Lines

Figure 5

Cell viability ((a) and (b)) and gene expression of RUNX2 ((c) and (d)), ALPL ((e) and (f)) and BGLAP ((g) and (h)) in Mg-63 (a, c, e, g) and Saos-2 (b, d, f, h) cultures 14 days after FUS treatment with different acoustic intensities. Mdn ± MAD (n = 4 replicates). For each cell type, cell viability was expressed as RF of untreated culture (0 W/cm²) and gene expression as , using gene expression of FUS untreated culture as calibrator. Mann Whitney U test between FUS intensities (, p < 0.05, , p < 0.005, , p < 0.0005).

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