Structural Basis for the Selective Inhibition of Cdc2-Like Kinases by CX-4945

Figure 2

Comparison of crystal packing between the wild-type (R431) and mutant (G431) molecules of CLK1. The trimeric CLK1 molecules in the asymmetric unit are colored in red, yellow, and blue. The neighbored symmetry-related molecules are presented as gray Cα ribbons. The side chains of Arg431 and Gly431 are shown in a green stick model. The detailed view of the packing interface is amplified in a black box.