Effect of Chemotherapeutics and Tocopherols on MCF-7 Breast Adenocarcinoma and KGN Ovarian Carcinoma Cell Lines In Vitro

Table 1

Concentrations of chemotherapeutics and tocopherols. Dox: doxorubicin, 4-Cyc: 4-hydroperoxycyclophosphamide, αToc: α-tocopherol, γToc: γ-tocopherol.

(a)

Single agents	Concentrations (μM)
Dox	0.5, 10, 25
4-Cyc	0, 0.5, 1, 2.5
αToc	0, 50, 75, 100
γToc	0, 50, 75, 100

(b)

Combined agents		Concentrations (μM)
Dox + 4-Cyc	Low	10 (Dox) + 1 (4-Cyc)
Dox + 4-Cyc	High	25 (Dox) + 2.5 (4-Cyc)
Dox + 4-Cyc + αToc	Low	10 (Dox) + 1 (4-Cyc) + 75 (αToc)
Dox + 4-Cyc + αToc	High	25 (Dox) + 2.5 (4-Cyc) 75 (αToc)
Dox + 4-Cyc + γToc	Low	10 (Dox) + 1 (4-Cyc) + 75 (γToc)
Dox + 4-Cyc + γToc	High	25 (Dox) + 2.5 (4-Cyc)+ 75 (γToc)