Pinelliae Rhizoma Praeparatum Cum Alumine Extract: Sedative and Hypnotic Effects in Mice and Component Compounds

Figure 3

Bouts of wakefulness and NREM sleep during the dark period. White, gray, and black bars show the profiles for the SWFI, PRPCA, and DZP groups, respectively. The negative time values on the X-axis represent the following periods, respectively: 0–16 s, 16–32 s, 32–64 s, 64–128 s, 128–256 s, 256–512 s, 512–1024 s, and 1024–2048 s. Data are expressed as the mean ± SEM; ^#P<0.05: PRPCA vs. SWFI; ^∆P<0.05 SWFI vs. DZP as assessed using ANOVA followed by the LSD test. NREM: nonrapid eye movement; SWFI: sterile water for injection; PRPCA: Pinelliae Rhizoma Praeparatum Cum Alumine; DZP: diazepam; ANOVA: analysis of variance; LSD: least significant difference.