Association of Kiss1 and GPR54 Gene Polymorphisms with Polycystic Ovary Syndrome among Sri Lankan Women

Table 3

Genotypes distribution in cases and controls.

Gene	SNP	Genotype	Cases	Controls	p	OR (95% CI)
			(n=55)	(n=110)
GPR54	rs10407968	A/G
		AA	37 (67%)	75 (65%)
		AG	18 (33%)	31 (27%)	0.649	0.850 (0.421 – 1.714)
		GG	00	09 (8%)	0.038	0.893 (0.829 – 0.962)
		AG + GG	18 (33%)	40 (35%	0.791	1.096 (0.555 – 2.167)
GPR54	rs1250729403	T/G
		TT	40 (71%)	90 (78%)
		TG	15 (27%)	25 (22%)	0.389	0.722 (0.344 – 1.517)
		GG	00	00
GPR54	rs350131	G/T
		GG	09 (16%)	24 (21%)
		GT	26 (47%)	53 (46%)	0.557	0.764 (0.311 – 1.877)
		TT	20 (36%)	38 (33%)	0.478	0.713 (0.279 – 1.821)
		GT + TT	46 (84%)	91 (79%)	0.487	0.742 (0.319 – 1.726)
GPR54	Chr19: 918686	A/G
	Gene:6345
		AA	37 (67%)	84 (73%)
		AG	18 (33%)	31 (27%)	0.394	0.738 (0.367 – 1.486)
		GG	00	00
GPR54	Chr19: 918735	A/G
	Gene:6394
		AA	26 (47%)	56 (49%)
		AG	28 (51%)	59 (51%)	0.947	0.978 (0.512 – 1.868)
		GG	00	00
KISS1	rs5780218	CTT/CT
		CTT/CTT	37 (67%)	68 (59%)
		CTT/CT	14 (25%)	42 (36%)	0.184	1.632 (0.790 – 3.372)
		CT/CT	04 (7%)	05 (4%)	0.581	0.680 (0.172 – 2.688)
		CTT/CT+ CT/CT	18 (32%)	47 (40%)	0.307	1.421 (0.723 – 2.790)
KISS1	rs4889	C/G
		CC	38 (69%)	67 (58%)
		CG	16 (29%)	42 (36%)	0.264	1.489 (0.739 – 2.998)
		GG	01 (2%)	06 (5%)	0.239	3.403 (0.395 – 29.334)
		CG + GG	17 (31%)	48 (41%)	0.174	1.601 (0.810 – 3.166)

OR: odds ratio; CI: confidence intervals; reference genotype.