Association of Kiss1 and GPR54 Gene Polymorphisms with Polycystic Ovary Syndrome among Sri Lankan Women

Table 4

Association between SNPs of GPR54 gene and PCOS risk under multiple models of inheritance.

SNP	Model	Genotype	Cases	Controls	OR (95%CI)	p	AIC	BIC
rs10407968	Co-dominant	A/A	38 (69.1%)	73 (66.4%)	1.00
		A/G	17 (30.9%)	28 (25.4%)	0.86 (0.42-1.76	0.021	208.3	217.6
		G/G	0 (0%)	9 (8.2%)	NA (0.00-NA)
	Dominant	A/A	38 (69.1%)	73 (66.4%)	1.00	0.72	213.9	220.1
		A/G-G/G	17 (30.9%)	37 (33.6%)	1.13 (0.57-2.27)
	Recessive	A/A-A/G	55 (100%)	101 (91.8%)	1.00	0.006	206.5	212.7
		G/G	0 (0%)	9 (8.2%)	NA (0.00-NA)
	Overdominant	A/A-G/G	38 (69.1%)	82 (74.5%)	1.00	0.46	213.5	219.7
		A/G	17 (30.9%)	28 (25.4%)	0.76 (0.37-1.56)
	Log-additive				1.39 (0.78-2.50)	0.25	212.7	219
rs1250729403		A/A	40 (72.7%)	81 (73.6%)	1.00	0.9	214	220.2
		A/G	15 (27.3%)	29 (26.4%)	0.95 (0.46-1.98)
rs350131		T/T	40 (72.7%)	90 (81.8%)	1.00	0.18	212.3	218.5
		T/G	15 (27.3%)	20 (18.2%)	0.59 (0.28-1.27)
Chr19: 918686		A/A	26 (47.3%)	52 (47.3%)	1.00	1	214	220.3
		A/G	29 (52.7%)	58 (52.7%)	1.00 (0.52-1.91)
	Co-dominant	T/T	19 (34.5%)	41 (37.3%)	1.00	0.068	210.7	220
Chr19: 918735		G/T	30 (54.5%)	43 (39.1%)	0.66 (0.32-1.36)
		G/G	6 (10.9%)	26 (23.6%)	2.01 (0.71-5.69
	Dominant	T/T	19 (34.5%)	41 (37.3%)	1.00	0.73	213.9	220.1
		G/T-G/G	36 (65.5%)	69 (62.7%)	0.89 (0.45-1.75)
	Recessive	T/T-G/T	49 (89.1%)	84 (76.4%)	1.00	0.043	209.9	216.2
		G/G	6 (10.9%)	26 (23.6%)	2.53 (0.97-6.57)
	Overdominant	T/T-G/G	25 (45.5%)	67 (60.9%)	1.00	0.06	210.5	216.7
		G/T	30 (54.5%)	43 (39.1%)	0.53 (0.28-1.03)
	Log-additive				1.21 (0.77-1.90)	0.4	213.4	219.6

AIC, Akaike information criteria; BIC, Bayesian information criteria; CI, confidence interval; OR: odds ratio.