Association of Kiss1 and GPR54 Gene Polymorphisms with Polycystic Ovary Syndrome among Sri Lankan Women

Table 5

Association between SNPs of Kiss1 gene and PCOS risk under multiple models of inheritance.

SNP	Model	Genotype	Cases	Controls	OR (95%CI)	p	AIC	BIC
rs5780218	Co-dominant	CTT/CTT	35 (63.6%)	59 (53.6%)	1.00	0.44	214.4	223.7
		CTT/CT	17 (30.9%)	45 (40.9%)	1.57 (0.78-3.15)
		CT/CT	3 (5.5%)	6 (5.5%)	1.19 (0.28-5.05)
	Dominant	CTT/CTT	35 (63.6%)	59 (53.6%)	1.00	0.22	212.5	218.8
		CTT/CT-CT/CT	20 (36.4%)	51 (46.4%)	1.51 (0.78-2.94)
	Recessive	CTT/CTT-CTT/CT	52 (94.5%)	104 (94.5%)	1.00	1	214	220.3
		CT/CT	3 (5.5%)	6 (5.5%)	1.00 (0.24-4.16)
	Overdominant	CTT/CTT-CT/CT	38 (69.1%)	65 (59.1%)	1.00	0.21	212.5	218.7
		CTT/CT	17 (30.9%)	45 (40.9%)	1.55 (0.78-3.08)
	Log-additive				1.33 (0.76-2.33)	0.31	213	219.2
	Co-dominant	C/C	36 (65.5%)	67 (60.9%)	1.00	0.61	215	224.4
rs4889		C/G	18 (32.7%)	38 (34.5%)	1.13 (0.57-2.27)
		G/G	1 (1.8%)	5 (4.5%)	2.69 (0.30-23.88)
	Dominant	C/C	36 (65.5%)	67 (60.9%)	1.00	0.57	213.7	219.9
		C/G-G/G	19 (34.5%)	43 (39.1%)	1.22 (0.62-2.39)
	Recessive	C/C-C/G	54 (98.2%)	105 (95.5%)	1.00	0.35	213.2	219.4
		G/G	1 (1.8%)	5 (4.5%)	2.57 (0.29-22.57)
	Over dominant	C/C-G/G	37 (67.3%)	72 (65.5%)	1.00	0.82	214	220.2
		C/G	18 (32.7%)	38 (34.5%)	1.08 (0.55-2.16)
	Log-additive				1.27 (0.70-2.29)	0.43	213.4	219.6

AIC, Akaike information criteria; BIC, Bayesian information criteria; CI, confidence interval; OR: odds ratio.