[Retracted] Second-Generation Histamine H1 Receptor Antagonists Suppress Delayed Rectifier K+-Channel Currents in Murine Thymocytes
Figure 2
Effects of azelastine and terfenadine on Kv1.3 channel currents in murine thymocytes. The effects of 100 μM azelastine (a) and 10 μM terfenadine (b). (A) Typical whole-cell current traces at different voltage-steps recorded before and after the application of either drug. The currents were elicited by voltage-steps from the holding potential of -80 mV to -40, 0, 40, and 80 mV, as depicted in the voltage protocol. Each pulse was applied for a 200-ms duration between 10-second intervals. (B) Peak current densities (peak currents normalized by the membrane capacitance) obtained from the records in (A) at the voltage-step of 80 mV. (C) Pulse-end current densities (pulse-end currents normalized by the membrane capacitance) obtained from the records in (A) at the voltage-step of 80 mV. # p < 0.05 vs. before the drug application. Values are means ± SEM (azelastine, n = 12; terfenadine, n = 9). Differences were analyzed by ANOVA followed by Dunnett’s or Student’s test.