Extracellular Signal-Regulated Kinase Mediates Ebastine-Induced Human Follicle Dermal Papilla Cell Proliferation

Figure 2

Ebastine-induced HFDPC growth. HFDPC were plated in triplicate in 24-well plates for 24 h. The cells were serum starved for 18 h and then treated with the indicated concentrations of ebastine ((a) and (b)) or 200 ng/mL ebastine along with indicated concentrations of fexofenadine for 24-48 h ((c) and (d)). Cell viability ((a) and (c)) and cell proliferation ((b) and (d)) were analyzed by WST-1 and bromodeoxyuridine (BrdU) assays, respectively. Representative results from three independent experiments are shown, and the data are presented as the mean ± SD after being normalized to the control group. indicates p < 0.05.

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