Research Article
The Association of Serum hsCRP and Urinary Alpha1-Microglobulin in Patients with Type 2 Diabetes Mellitus
Table 1
Clinical and biological characteristics of the patients studied by gender.
| | Characteristics | Total | Male | Female | P value |
| | Biological parameters | | Case number | 520 | 317 | 203 | | | Age (year-old) | 58.59±12.54 | 57.05±12.86 | 60.98±11.65 | 0.001 | | Duration of T2DM | 12.69±5.50 | 12.69±5.45 | 12.68±5.60 | 0.852 | | BMI (kg/m2) | 25.32±3.57 | 25.33±3.57 | 25.30±3.57 | 0.816 | | Systolic BP (mmHg) | 131.03±16.66 | 130.22±15.71 | 132.30±18.01 | 0.657 | | Diastolic BP (mmHg) | 77.39±10.92 | 77.73±10.93 | 76.87±10.89 | 0.517 | | Biochemical and metabolic parameters | | hsCRP (mg/L) | 1.31(0.51-3.27) | 1.08(0.50-3.03) | 1.90 (0.58-3.87) | 0.026 | | FPG (mmol/L) | 7.56(5.91-9.59) | 7.39 (5.98-9.10) | 7.78 (5.81-10.17) | 0.292 | | BUN (mmol/L) | 5.60(4.60-6.80) | 5.60(4.55-6.80) | 5.50 (4.60-6.90) | 0.425 | | SCr(μmol/L) | 65.60(53.56-77.50) | 67.00(56.60-81.55) | 59.20 (49.80-73.80) | <0.001 | | UA(μmol/L) | 339.80(286.73-404.03) | 345.90(302.30-414.85) | 316.30(277.80-381.14) | <0.001 | | TP(g/L) | 64.90±5.29 | 64.58±5.16 | 65.39±5.47 | 0.168 | | ALB(g/L) | 39.70(37.50-42.10) | 39.70(37.40-42.05) | 39.70 (37.60-42.10) | 0.412 | | LPa (mg/dL) | 11.92(5.10-26.75) | 10.90 (4.30-25.30) | 13.20 (6.10-27.50) | 0.106 | | TG (mmol/L) | 1.50(1.05-2.31) | 1.47(1.03-2.34) | 1.57 (1.11-2.27) | 0.355 | | TC (mmol/L) | 4.25(3.59-5.03) | 4.22(3.52-4.87) | 4.44 (3.72-5.46) | 0.005 | | LDL-C (mmol/L) | 2.42 (1.86-3.10) | 2.39(1.84-2.99) | 2.45 (1.92-3.23) | 0.087 | | HDL-C (mmol/L) | 1.03(0.86-1.25) | 1.02(0.85-1.21) | 1.07 (0.90-1.32) | 0.009 | | Insulin (fasting)(uIU/mL) | 7.40(4.50-12.50) | 7.40(4.50-12.10) | 7.40 (4.33-13.43) | 0.807 | | C-peptide (fasting)(ng/mL) | 1.17(1.10-2.60) | 1.70(1.20-2.50) | 1.70(1.10-2.68) | 0.575 | | HOMA-IR | 2.32(1.31-4.03) | 2.23(1.31-3.98) | 2.40 (1.30-4.14) | 0.893 | | HbA1C(%) | 8.84±1.91 | 8.91±1.94 | 8.71±1.88 | 0.240 | | eGFR (ml/min/1.73m2) | 100.35(82.59-112.50) | 105.70(92.71-117.63) | 92.26 (74.79-101.70) | <0.001 | | Urinary protein parameters | | UA1MG (mg/gCr) | 10.23 (5.85-19.94) | 9.47(5.55-19.09) | 11.44 (6.78-20.677) | 0.134 | | UACR (mg/ gCr) | 15.21(7.53-58.83) | 14.42(7.10-54.84) | 17.66 (8.35-61.88) | 0.307 | | UIGG (mg/gCr) | 6.59(3.90-13.50) | 5.87(3.52-11.27) | 8.08 (4.76-14.62) | <0.001 | | UTRF (mg/gCr) | 3.20(2.00-6.00) | 2.90(1.80-5.35) | 3.90 (2.40-6.50) | 0.001 |
|
|
Data are shown as mean±SD or median (IQR).
T2DM:type 2 diabetes mellitus; hsCRP: hypersensitive C-reactive protein; BMI:Body mass index; IQR: interquartile range; FPG: fasting plasma glucose; BUN: blood urea nitrogen; SCr: serum creatinine; UA: serum uric acid; TP: total protein; ALB: albumen Lpa: Lipoprotein a; TG: Triglycerides; TC:Total cholesterol; LDL-C: low density lipoprotein-cholesterol; HDL-C: high density lipoprotein-cholesterol; HOMA-IR:homeostasis model assessment-insulin resistance; HbA1C: glycosylated hemoglobin; eGFR: estimated glomerular filtration rate; UA1MG: Urinary alpha1-microglobulin to creatinine ratio; UACR: Urinary microalbumin to creatinine ratio; UIGG: Urinary immunoglobulin G to creatinine ratio; UTRF: Urinary transferrin to creatinine ratio; SD: standard deviation; IQR: interquartile range.
|
