Research Article
The Association of Serum hsCRP and Urinary Alpha1-Microglobulin in Patients with Type 2 Diabetes Mellitus
Table 2
Clinical and biological characteristics of the patients studied by serum hsCRP group.
| | characteristics | Low hsCRP group
(hsCRP≤3mg/L) | High hsCRP group
(hsCRP>3mg/L) | P value |
| | Biological parameters | | Case number (Male/ Female) | 379(238/141) | 141(79/62) | | | Age (year-old) | 58.09±13.15 | 59.92±10.67 | 0.333 | | Duration of T2DM | 13.04±5.34 | 11.75±5.90 | 0.090 | | BMI (kg/m2) | 24.70±3.20 | 26.93±3.99 | <0.001 | | Systolic BP (mmHg) | 131.19±16.23 | 130.60±17.81 | 0.803 | | Diastolic BP (mmHg) | 77.27±11.04 | 77.71±10.62 | 0.337 | | Biochemical and metabolic parameters | | hsCRP (mg/L) | 0.80(0.40-1.49) | 5.50 (4.12-7.96) | <0.001 | | FPG (mmol/L) | 7.30(5.76-9.11) | 8.13 (6.35-10.41) | 0.003 | | BUN (mmol/L) | 5.70(4.60-6.90) | 5.40 (4.50-6.60) | 0.131 | | SCr(μmol/L) | 66.30(54.80-77.90) | 61.90(52.25-77.25) | 0.314 | | UA(μmol/L) | 333.30(283.50-403.50) | 353.50(301.15-408.70) | 0.166 | | TP(g/L) | 64.72±5.25 | 65.38±5.38 | 0.053 | | ALB(g/L) | 40.10(37.90-42.70) | 38.80(36.30-40.95) | <0.001 | | LPa (mg/dL) | 11.70 (5.20-27.00) | 12.60 (4.60-24.30) | 0.716 | | TG (mmol/L) | 1.47(1.00-2.21) | 1.66 (1.18-2.48) | 0.017 | | TC (mmol/L) | 4.22(3.55-5.02) | 4.39 (3.70-5.03) | 0.234 | | LDL-C (mmol/L) | 2.37(1.84-3.05) | 2.57(1.96-3.19) | 0.122 | | HDL-C (mmol/L) | 1.06(0.88-1.29) | 0.95(0.81-1.14) | 0.001 | | Insulin (fasting)(uIU/mL) | 6.75(4.10-11.88) | 9.30(5.50-14.50) | 0.002 | | C-peptide (fasting)(ng/mL) | 1.60(1.10-2.40) | 2.00(1.30-3.00) | 0.001 | | HOMA-IR | 2.07(1.19-3.76) | 2.79(1.58-5.03) | 0.004 | | HbA1C(%) | 8.71±1.87 | 9.16±1.99 | 0.024 | | eGFR (ml/min/1.73m2) | 100.19(82.60-113.17) | 101.10(80.7-111.657) | 0.533 | | Urinary protein parameters | | UA1MG (mg/gCr) | 9.47(5.50-17.07) | 14.22(7.26-30.99) | <0.001 | | UACR (mg/ gCr) | 15.03(7.20-58.83) | 19.47 (8.19-57.79) | 0.371 | | UIGG (mg/gCr) | 6.21(3.61-10.98) | 7.81 (4.65-16.11) | 0.001 | | UTRF (mg/gCr) | 3.20(1.90-5.90) | 3.50(2.20-8.25) | 0.099 |
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Data are shown as mean±SD or median (IQR).
T2DM:type 2 diabetes mellitus; hsCRP: hypersensitive C-reactive protein; BMI:Body mass index; IQR: interquartile range; FPG: fasting plasma glucose; BUN: blood urea nitrogen; SCr: serum creatinine; UA: serum uric acid; TP: total protein; ALB: albumen Lpa: Lipoprotein a; TG: Triglycerides; TC:Total cholesterol; LDL-C: low density lipoprotein-cholesterol; HDL-C: high density lipoprotein-cholesterol; HOMA-IR:homeostasis model assessment-insulin resistance; HbA1C: glycosylated hemoglobin; eGFR: estimated glomerular filtration rate; UA1MG: Urinary alpha1-microglobulin to creatinine ratio; UACR: Urinary microalbumin to creatinine ratio; UIGG: Urinary immunoglobulin G to creatinine ratio; UTRF: Urinary transferrin to creatinine ratio; SD: standard deviation; IQR: interquartile range.
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