The Association of Serum hsCRP and Urinary Alpha1-Microglobulin in Patients with Type 2 Diabetes Mellitus
Table 4
Multivariate linear regression for effects of serum hsCRP on each urinary protein parameter.
parameters
Model 1
Model 2
Model 3
β (SE)
P
β(SE)
P
β (SE)
P
LnUA1MG
LnhsCRP
0.179 (0.030)
<0.001
0.169 (0.029)
<0.001
0.122(0.027)
<0.001
hsCRP≤3mg/L
Ref.
Ref.
Ref.
hsCRP>3mg/L
0.452 (0.089)
<0.001
0.419 (0.087)
<0.001
0.317(0.078)
<0.001
LnUACR
LnhsCRP
0.101 (0.057)
0.080
0.091 (0.057)
0.112
-0.012(0.052)
0.825
hsCRP≤3mg/L
Ref.
Ref.
Ref.
hsCRP>3mg/L
0.207 (0.167)
0.216
0.175 (0.167)
0.294
-0.068(0.148)
0.649
LnUIGG
LnhsCRP
0.148(0.038)
<0.001
0.135 (0.038)
<0.001
0.039(0.033)
0.234
hsCRP≤3mg/L
Ref.
Ref.
Ref.
hsCRP>3mg/L
0.428 (0.112)
<0.001
0.389 (0.110)
<0.001
0.162(0.094)
0.085
LnUTRF
LnhsCRP
0.094 (0.039)
0.016
0.081 (0.038)
0.034
0.014(0.035)
0.694
hsCRP≤3mg/L
Ref.
Ref.
Ref.
hsCRP>3mg/L
0.251 (0.113)
0.027
0.212 (0.111)
0.057
0.036(0.099)
0.713
Model 1 univariate analysis Model 2 adjusted for age and gender Model 3 adjusted for duration of T2DM, systolic BP, FPG, BUN, TP, ALB, LDL-C, eGFR hsCRP: hypersensitive C-reactive protein; UA1MG: Urinary alpha1-microglobulin to creatinine ratio; UACR: Urinary microalbumin to creatinine ratio; UIGG: Urinary immunoglobulin G to creatinine ratio; UTRF: Urinary transferrin to creatinine ratio.
