The Association of Serum hsCRP and Urinary Alpha1-Microglobulin in Patients with Type 2 Diabetes Mellitus
Table 5
Multivariate logistic regression for effects of serum hsCRP on each urinary protein parameter.
parameters
Model 1
Model 2
Model 3
OR (95%CI)
P
OR (95%CI)
P
OR (95%CI)
P
UA1MG >10(mg/gCr)
LnhsCRP
1.297 (1.128-1.491)
<0.001
1.282 (1.112-1.478)
0.001
1.366(1.147-1.626)
<0.001
hsCRP≤3mg/L
Ref.
Ref.
Ref.
hsCRP>3mg/L
1.576 (1.064- 2.334)
0.023
1.498 (1.005- 2.234)
0.047
1.610(1.037-2.499)
0.034
UACR>30(mg/gCr)
LnhsCRP
1.045 (0.904- 1.207)
0.552
1.032(0.892-1.194)
0.669
1.022(0.876-1.204)
0.797
hsCRP≤3mg/L
Ref.
Ref.
Ref.
hsCRP>3mg/L
0.911 (0.594-1.399)
0.670
0.880 (0.571-1.354)
0.561
0.933(0.579-1.505)
0.777
UIGG >5(mg/gCr)
LnhsCRP
1.165 (1.012- 1.342)
0.034
1.138(0.985-1.314)
0.078
1.140(0.977-1.331)
0.096
hsCRP≤3mg/L
Ref.
Ref.
Ref.
hsCRP>3mg/L
1.510 (0.996-2.289)
0.052
1.407(0.922-2.147)
0.114
1.478(0.939-2.326)
0.091
UTRF >1.5(mg/gCr)
LnhsCRP
1.117 (0.926-1.348)
0.247
1.072(0.883-1.301)
0.485
1.101(0.899-1.348)
0.352
hsCRP≤3mg/L
Ref.
Ref.
Ref.
hsCRP>3mg/L
1.617 (0.901-2.903)
0.107
1.404(0.770-2.558)
0.268
1.547(0.831-2.881)
0.169
Model 1 univariate analysis Model 2 adjusted for age and gender Model 3 adjusted for duration of T2DM, systolic BP, FPG, BUN, TP, ALB, LDL-C, eGFR hsCRP: hypersensitive C-reactive protein; UA1MG: Urinary alpha1-microglobulin to creatinine ratio; UACR: Urinary microalbumin to creatinine ratio; UIGG: Urinary immunoglobulin G to creatinine ratio; UTRF: Urinary transferrin to creatinine ratio.
