MiR-455-5p Suppresses the Progression of Prostate Cancer by Targeting CCR5

Figure 3

CCR5 as a direct target of miR-455-5p. (a) Diagram of putative miR-455 binding sites in the 3′-UTR (397–412) of CCR5 mRNA. (b) Relative activities of luciferase reporters containing CCR5 3′-UTR variants cotransfected with miR-455-5p or negative-control mimics in LNCAP and DU145 cells. (c) Protein levels of CCR5 72 h after miR-455-5p and inhibitor transfection in LNCAP and DU145 cells. , P < 0.05; , P < 0.01; , P < 0.001.

(a)

(b)

(c)