Research Article
Fungal Keratitis: Epidemiology, Rapid Detection, and Antifungal Susceptibilities of Fusarium and Aspergillus Isolates from Corneal Scrapings
Table 3
Minimum inhibitory concentration (μg/ml) of antifungal agents against Aspergillus spp.
| | Amphotericin B | |
| | Isolates | MIC range | ≤0.5 μg/ml | ≥1 μg/ml | MIC50 | MIC90 |
| | A. flavus (n = 47) | 8 – 0.25 | 21 (44.7%) | 26 (53.4%) | 1 | 2 | | A. fumigatus (n = 11) | 4 – 0.25 | 5 (45.4%) | 6(54.5%) | 1 | 4 | | A. terreus (n = 5) | 2 – 0.5 | 2 (40%) | 3 (60%) | 1 | 2 | | A. niger (n = 3) | 0.5 – 0.25 | 3 (100%) | - | 0.5 | 0.5 | | A. tamarii (n = 1) | NA | 1 (100%) | - | NA | NA |
| | Natamycin | |
| | Isolates | MIC range | ≤16 μg/ml | ≥32 μg/ml | MIC50 | MIC90 |
| | A. flavus (n = 47) | 64 – 16 | 18 (38.2%) | 29 (61.7%) | 32 | 64 | | A. fumigatus (n = 11) | 64 – 16 | 7 (63.6%) | 4 (36.3%) | 16 | 32 | | A. terreus (n = 5) | 32 – 16 | 1 (20%) | 4 (80%) | 32 | 32 | | A. niger (n = 3) | 32 – 8 | 2 (66.7%) | 1 (33.4%) | 16 | 32 | | A. tamarii (n = 1) | NA | - | 1 (100%) | NA | NA |
| | Itraconazole | |
| | Isolates | MIC range | ≤0.25 μg/ml | ≥0.5 μg/ml | MIC50 | MIC90 |
| | A. flavus (n = 47) | 1 – 0.25 | 25 (53.1%) | 22 (46.8%) | 0.25 | 0.5 | | A. fumigatus (n = 11) | 0.5 – 0.25 | 5 (45.4%) | 6 (54.5%) | 0.5 | 0.5 | | A. terreus (n = 5) | NA | - | 5 (100%) | 0.5 | 0.5 | | A. niger (n = 3) | 0.5 – 0.25 | 2 (66.7%) | 1 (33.4%) | 0.25 | 0.5 | | A. tamarii (n = 1) | NA | 1 (100%) | - | NA | NA |
| | Voriconazole | |
| | Isolates | MIC range | ≤0.5 μg/ml | ≥1 μg/ml | MIC50 | MIC90 |
| | A. flavus (n = 47) | 4 – 0.25 | 37 (78.7%) | 10 (21.2%) | 0.5 | 1 | | A. fumigatus (n = 11) | 4 – 0.25 | 6 (54.5%) | 5 (45.4%) | 0.5 | 1 | | A. terreus (n = 5) | 1 – 0.5 | 3 (60%) | 2 (40%) | 0.5 | 1 | | A. niger (n = 3) | 1 – 0.25 | 2 (66.7%) | 1 (33.4%) | 0.5 | 1 | | A. tamarii (n = 1) | NA | - | 1 (100%) | NA | NA |
| | Econazole | |
| | Isolates | MIC range | ≤0.5 μg/ml | ≥1 μg/ml | MIC50 | MIC90 |
| | A. flavus (n = 47) | 2 – 0.25 | 37 (78.7%) | 10 (21.2%) | 0.5 | 1 | | A. fumigatus (n = 11) | 1 – 0.25 | 5 (45.4%) | 6 (54.5%) | 1 | 1 | | A. terreus (n = 5) | 1 – 0.5 | 2 (40%) | 3 (60%) | 0.5 | 1 | | A. niger (n = 3) | 2 – 0.25 | 1 (33.4%) | 2 (66.7%) | 2 | 2 | | A. tamarii (n = 1) | NA | - | 1 (100%) | NA | NA |
| | Clotrimazole | |
| | Isolates | MIC range | ≤0.5 μg/ml | ≥1 μg/ml | MIC50 | MIC90 |
| | A. flavus (n = 47) | 1 – 0.125 | 31 (65.9%) | 16 (34%) | 0.5 | 1 | | A. fumigatus (n = 11) | 1 – 0.125 | 8 (72.7%) | 3 (27.2%) | 0.5 | 1 | | A. terreus (n = 5) | 1 – 0.5 | 1 (20%) | 4 (80%) | 1 | 1 | | A. niger (n = 3) | 1 – 0.5 | 1 (33.4%) | 2 (66.7%) | 1 | 1 | | A. tamarii (n = 1) | NA | 1 (100%) | - | NA | NA |
| | Ketoconazole | |
| | Isolates | MIC range | ≤0.5 μg/ml | ≥1 μg/ml | MIC50 | MIC90 |
| | A. flavus (n = 47) | 8 – 0.5 | 14 (29.7%) | 33 (70.2%) | 1 | 4 | | A. fumigatus (n = 11) | 4 – 0.125 | 4 (36.3%) | 7 (63.6%) | 1 | 2 | | A. terreus (n = 5) | 4 – 1 | - | 5 (100%) | 2 | 4 | | A. niger (n = 3) | 4 – 0.5 | 1 (33.4%) | 2 (66.7%) | 1 | 4 | | A. tamarii (n = 1) | NA | - | 1 (100%) | NA | NA |
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NA: not applicable.
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