Clinical Efficacy of Extracorporeal Cardiopulmonary Resuscitation for Adults with Cardiac Arrest: Meta-Analysis with Trial Sequential Analysis

Figure 3

(a) Forest plot of studies reporting 30-day favorable neurologic outcome. (b) Random-effect model of trial sequential analysis for 30-day favorable neurologic outcome. Type 1 error is =5%. A diversity-adjusted information size of 2063 participants calculated on the basis of a good neurologic outcome rate of 7.8% in the CCPR group, 20% increase in outcome, α = 5% (two sided), β = 20%, and = 46%. Complete blue line represents cumulative Z-curve, which crossed conventional boundary (dashed red line) and the trial sequential monitoring (dashed gray line).

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