Clinical Efficacy of Extracorporeal Cardiopulmonary Resuscitation for Adults with Cardiac Arrest: Meta-Analysis with Trial Sequential Analysis

Figure 5

(a) Random-effect model of trial sequential analysis for 30-day survival outcome in OHCA patients. Type 1 error is =5%; a diversity-adjusted information size of 6257 participants calculated on the basis of a survival rate of 16.6% in the CCPR group, 20% increase in outcome, α = 5% (two sided), β = 20%, and = 40%. Complete blue line represents cumulative Z-curve, which does not cross the conventional boundary (dashed red line) or the trial sequential monitoring boundary (dashed gray line). (b) Random-effect model of trial sequential analysis for 30-day survival outcome in IHCA patients. Type 1 error is =5%; a diversity-adjusted information size of 2190 participants calculated on the basis of a survival rate of 14.8% in the CCPR group, 20% increase in outcome, α = 5% (two sided), β = 20%, and = 0%. Complete blue line represents cumulative Z-curve, which crossed conventional boundary (dashed red line) and the trial sequential monitoring boundary (dashed gray line).

(a)

(b)