Single Nucleotide Polymorphisms of CBX4 and CBX7 Decrease the Risk of Hepatocellular Carcinoma
Table 3
Associations between SNPs and HCC.
Genotypes
Cases [ (%)]
Controls [ (%)]
OR (95% CI)
P-value
FDR
n
%
n
%
rs7217395
CC
154
46.11
138
42.99
1
-
-
CT
129
38.62
137
42.68
0.97 (0.60-1.58)
0.90
0.90
TT
33
9.88
26
8.10
1.41 (0.63-3.16
0.40
0.60
CT/TT
162
48.50
163
50.78
1.04 (0.66-1.65)
0.87
0.89
Genotyping failed
18
5.39
20
6.23
-
-
rs2036316
CC
95
28.44
94
29.28
1
-
CT
136
40.72
132
41.12
0.91 (0.52-1.57)
0.72
0.90
TT
86
25.75
68
21.18
1.30 (0.70-2.42)
0.40
0.60
CT/TT
222
66.47
200
62.31
1.04 (0.63-1.72)
0.89
0.89
Genotyping failed
17
5.09
27
8.41
-
-
rs3764374
CC
214
64.07
161
50.16
1
-
CT
101
30.24
100
31.15
1.24 (0.75-2.04)
0.40
0.72
TT
16
4.79
14
4.36
0.78 (0.27-2.23)
0.64
0.82
CT/TT
117
35.03
114
35.51
1.16 (0.72-1.87)
0.53
0.80
Genotyping failed
3
0.90
46
14.33
-
-
rs1285251
CC
165
49.40
152
47.35
1
-
CT
120
35.93
132
41.12
1.16 (0.72-1.88)
0.55
0.83
TT
43
12.87
18
5.61
2.260 (0.99-5.16)
0.05
0.45
CT/TT
163
48.80
150
46.73
1.31 (0.83-2.08)
0.24
0.43
Genotyping failed
6
1.80
19
5.92
-
-
rs2289728
GG
116
34.73
88
27.41
1
-
GA
146
43.71
152
47.35
0.56 (0.33-0.94)
0.03
0.14
AA
66
19.76
64
19.94
0.63 (0.33-1.22)
0.17
0.51
GA/AA
212
63.47
216
67.29
0.58 (0.35-0.94)
0.03
0.23
Genotyping failed
6
1.80
17
5.30
-
-
rs7292074
AA
120
35.93
135
42.06
1
-
CA
152
45.51
143
44.55
0.52 (0.25-1.07)
0.08
0.24
CC
54
16.17
30
9.35
0.67 (0.33-1.36)
0.26
0.59
CA/CC
206
61.68
173
53.89
1.41 (0.89-0.24
0.15
0.34
Genotyping failed
8
2.40
13
4.05
-
-
rs710190
TT
199
59.58
176
54.83
1
-
CT
113
33.83
106
33.02
1.05 (0.65-1.71)
0.84
0.90
CC
17
5.09
18
5.61
1.04 (0.38-2.88)
0.94
0.94
CT/CC
130
38.92
124
38.63
1.05 (0.66-1.67)
0.84
0.89
Genotyping failed
5
1.50
21
6.54
-
-
rs139394
CC
186
55.69
147
45.79
1
-
CA
106
31.74
128
39.88
0.55 (0.33-0.90)
0.02
0.14
AA
35
10.48
25
7.88
1.07 (0.47-2.43)
0.87
0.94
CA/AA
141
42.22
153
47.66
0.63 (0.39-0.99)
0.05
0.23
Genotyping failed
7
2.10
21
6.54
-
-
rs5750753
CC
82
24.55
99
30.84
1
-
CG
158
47.31
141
43.93
1.54 (0.90-2.62)
0.12
0.27
GG
86
25.75
67
20.87
1.57 (0.83-2.96)
0.17
0.51
CG/GG
244
73.05
208
64.80
1.55 (0.93-2.56)
0.09
0.27
Genotyping failed
8
2.40
14
4.36
-
-
Bold values indicate statistical significance. a: adjusted age, gender, smoking habits, alcohol intake, and HBsAg values after logistic regression. Values of these covariates in logistic regression models were shown in Table S1.
