Inhibition of the Nrf2-TrxR Axis Sensitizes the Drug-Resistant Chronic Myelogenous Leukemia Cell Line K562/G01 to Imatinib Treatments
Knockdown of Nrf2 significantly increased the apoptosis ratio of K562/G01 cells after imatinib treatments. (a) Representative flow cytometric profiles showed the Annexin V and PI staining patterns in indicated cell lines at 28 hours after treatments with 6 μM and 20 μM imatinib. (b) Summary data on the percentage of apoptosis ratio (Annexin V-positive cells among total cells) in the indicated cell lines treated with (6 μM and 20 μM) or without (0 μM) imatinib. n = 3 for each group; , compared with the control group and the blank K562/G01 cells group.