Examining Socioeconomic and Computational Aspects of Vaccine Pharmacovigilance

Figure 1

VAERS review approach: we process public VAE reports from VAERS to identify serious events, annotate polypharmacy cases, and highlight those in which drugs may interact with each other regardless of vaccine activity interference. Among other content, VAERS contains data regarding adverse vaccine incidences, respective outcomes, reported symptoms, information about vaccine administration, diagnostic laboratory data, preexisting and current conditions, and narratives about (prescription, or not) medications that the vaccine-recipient was taking at the time of vaccination. Next to disproportionality measures, we utilize enrichment-analytics to compare reaction incidence between cases with and without drug interference. We also summarize VAE reports to provide vaccine safety profiles.