Examining Socioeconomic and Computational Aspects of Vaccine Pharmacovigilance

Table 4

Summary of vaccine safety profiles: our analysis reduced large part of the original candidate set of associations. Our threshold criteria required statistical significance, PRR values to be larger than one, and the signals to be observed in more than ten VAEs. This is reflected by the increased average values observed for relationships included in the summarized profiles. These contain some extreme values that, for example, may occur when almost all incidences of a symptom appear in VAEs of one vaccine type.

Totals	Unprocessed set	Profile summary
Symptom-to-vaccine combos	132093	11287
Vaccine types	90	80
Symptoms	10169	2133
Averages	Unprocessed set	Profile summary
VAEs per vaccine type	10614.2	11938.25
Symptoms per vaccine type	1467.7	141.09
PRR score (symptom-vaccine type)	-	11.37
% symptom occurrence per vaccine type	0.3	1.34