Integrative Analysis Reveals Comprehensive Altered Metabolic Genes Linking with Tumor Epigenetics Modification in Pan-Cancer

Figure 1

Cancer-induced changes in all gene and metabolic gene expressions. (a) The number of EGs, DEGs, and MDEGs in 11 different cancer types. Orange bar represents EGs, green bar represents DEGs, and purple bar represents MDEGs in 11 different cancer types. (b) The number of significantly upregulated and downregulation of MDEGs in 11 types of cancers. Significantly different genes were filtrated by the following criteria: FDR > 0.5, |Fold Change| > 1.5. Red and green bars represent upregulated and downregulation MDEGs, respectively, in 11 cancer types. (c) Heat map of differentially expressed genes in TCGA and GEO database. Red color represents the upregulated genes; blue color represents the downregulated genes; white color represents genes without change. EGs: expressed genes; DEGs: differentially expressed genes; MDEGs: metabolic differential expression genes; BRCA: breast invasive carcinoma; COAD: colon adenocarcinoma; COADREAD: colon rectum adenocarcinoma; HNSC: head and neck squamous cell carcinoma; KIRC: kidney renal clear cell carcinoma; KIRP: kidney renal papillary cell carcinoma; LIHC: liver hepatocellular carcinoma; LUAD: lung adenocarcinoma; LUSC: lung squamous cell carcinoma; STAD: stomach adenocarcinoma; THCA: thyroid carcinoma; TCGA: the cancer genome atlas; GEO: Gene Expression Omnibus.

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